Interesting to see that blue light plays an important role in osteoblast health.  These are the cells that help us build healthy bones.  While blue light had not been thought to penetrate as deeply into bone as red and infrared wavelengths it does seem to have a critical role in the calcium ion channel and on promoting bone health.
Sci Rep. 2016 Sep 21;6:33719. doi: 10.1038/srep33719.

Photobiomodulation (blue and green light) encourages osteoblastic-differentiation of human adipose-derived stem cells: role of intracellular calcium and light-gated ion channels.

Wang Y1,2,3,4, Huang YY3,4, Wang Y1,2, Lyu P1,2, Hamblin MR3,4,5.


Human adipose-derived stem cells (hASCs) have the potential to differentiate into several different cell types including osteoblasts. Photobiomodulation (PBM) or low level laser therapy (LLLT) using red or near-infrared wavelengths has been reported to have effects on both proliferation and osteogenic differentiation of stem cells. We examined the effects of delivering four different wavelengths (420 nm, 540 nm, 660 nm, 810 nm) at the same dose (3 J/cm(2)) five times (every two days) on hASCs cultured in osteogenic medium over three weeks. We measured expression of the following transcription factors by


RUNX2, osterix, and the osteoblast protein, osteocalcin. The 420 nm and 540 nm wavelengths were more effective in stimulating osteoblast differentiation compared to 660 nm and 810 nm. Intracellular calcium was higher after 420 nm and 540 nm, and could be inhibited by capsazepine and SKF96365, which also inhibited osteogenic differentiation. We hypothesize that activation of light-gated calcium ion channels byblue and green light could explain our results.

[PubMed – in process]

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